Cannabis could help treat inflammatory bowel diseases which affect millions, first study shows
Marijuana ingredient mimics body’s inflammation off-switch and could lead to new drug targets for Crohn’s and colitis
Chemicals in cannabis can mimic the signals the body uses to regulate inflammation in the gut and could help treat serious chronic bowel conditions like Chron’s disease and ulcerative colitis, scientists have said. Research from the University of Bath said the findings could help explain why some patients with inflammatory bowel diseases (IBD) report medical marijuana can help their symptoms. The trials are only in mice at this stage, but could lead to new drug targets for disorders which affect millions of people around the world.
Professor Randy Mrsny, from the University of Bath’s Department of Pharmacy and Pharmacology, said: “We need to be clear that while this is a plausible explanation for why marijuana users have reported cannabis relieves symptoms of IBD, we have only worked in mice and have not proven this experimentally in humans. “However our results may provide a mechanistic explanation for anecdotal data that cannabinoid exposure benefits some colitis patients. “For the first time we have identified a counterbalance to the inflammation response in the intestine and we hope that these findings will help us develop new ways to treat bowel diseases.” Crohn’s disease and ulcerative colitis are the two most common forms of inflammatory bowel disease and affect 300,000 people in the UK, according to Crohn’s and Colitis UK.
They are chronic conditions and over a life-time the repeated damage from inflammation to the cells of the gut and intestine can require surgery for complications. The researchers from Bath worked with colleagues at the University of Massachusetts Medical School to conduct their study, which is published in the Journal of Clinical Investigation.
They found gut inflammation is regulated by two processes, which are constantly in flux to respond to changing conditions in intestines. Previous research identified the first process – a pathway promoting an aggressive immune response in the gut, which is useful to destroy dangerous pathogens but can damage the lining of the intestine when immune cells attack indiscriminately.
The second process, revealed in the new research, turns off this inflammation response via molecules transported across the cells lining the gut into the intestine cavity. This response requires a naturally-produced molecule called endocannabinoid, which is very similar to cannabinoid molecules found in cannabis, the researchers say. If the endocannabinoid is not present, inflammation is not kept in balance and can flare up as the body’s immune system cells attack the intestinal lining. The researchers believe that, because cannabis use introduces cannabinoids into the body, these molecules could help relieve gut inflammation as the naturally produced endocannabinoids would.
Professor Beth McCormick, from the University of Massachusetts Medical School, said: “There’s been a lot of anecdotal evidence about the benefits of medical marijuana, but there hasn’t been a lot of science to back it up. “For the first time, we have an understanding of the molecules involved in the process and how endocannabinoids and cannabinoids control inflammation. “This gives clinical researchers a new drug target to explore to treat patients that suffer from inflammatory bowel diseases, and perhaps other diseases, as well.”